Sequence Detail

ID/Version

P15314 (UniProt | EBI)

Last sequence update: 1990-04-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interferon regulatory factor 1; Short=IRF-1;

Provider

SWISS-PROT

Sequence

Polypeptide 329 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irf1	interferon regulatory factor 1	77	121	4	20

Sequence references in MGI

J:17555 Miyamoto M, et al., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988 Sep 9;54(6):903-13
J:115304 Negishi H, et al., Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15136-41
J:137875 Fragale A, et al., IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression. J Immunol. 2008 Aug 1;181(3):1673-82
J:144079 Kim EJ, et al., Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1. Biochem Biophys Res Commun. 2008 Dec 19;377(3):952-6
J:160488 Stirnweiss A, et al., IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol. 2010 May 1;184(9):5179-85
J:183131 Brien JD, et al., Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog. 2011 Sep;7(9):e1002230
J:183979 Taniguchi T, et al., IRF family of transcription factors as regulators of host defense. Annu Rev Immunol. 2001;19:623-55
J:231714 Man SM, et al., The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat Immunol. 2015 May;16(5):467-75
J:236523 Man SM, et al., IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016 Oct 6;167(2):382-396.e17
J:258250 Kuriakose T, et al., IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018 Feb 15;200(4):1489-1495
J:279203 Daniels BP, et al., The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019 Jan 15;50(1):64-76.e4