Sequence Detail

ID/Version

P15392 Q91XG2 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Cytochrome P450 2A4; EC=1.14.14.1;AltName: Full=CYPIIA4;AltName: Full=Cytochrome P450-15-alpha;AltName: Full=Cytochrome P450-IIA3.1;AltName: Full=Testosterone 15-alpha-hydroxylase;

Provider

SWISS-PROT

Sequence

Polypeptide 494 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyp2a4	cytochrome P450, family 2, subfamily a, polypeptide 4	19	103	5	2

Sequence references in MGI

J:30925 Lindberg RL, et al., Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature. 1989 Jun 22;339(6226):632-4
J:30944 Squires EJ, et al., Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene. J Biol Chem. 1988 Mar 25;263(9):4166-71
J:37044 Lindberg R, et al., The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene. J Biol Chem. 1989 Apr 15;264(11):6465-71
J:120430 Lavery DJ, et al., Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Mol Cell Biol. 1999 Oct;19(10):6488-99