Sequence Detail

ID/Version

P17427 Q921V0 Q8C2J5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=AP-2 complex subunit alpha-2 {ECO:0000305};AltName: Full=100 kDa coated vesicle protein C;AltName: Full=Adaptor protein complex AP-2 subunit alpha-2;AltName: Full=Adaptor-related protein complex 2 subunit alpha-2;AltName: Full=Alpha-adaptin

Provider

SWISS-PROT

Sequence

Polypeptide 938 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ap2a2	adaptor-related protein complex 2, alpha 2 subunit	32	97	2	48

Sequence references in MGI

J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
J:47962 Jurecic R, et al., Identification and cloning of differentially expressed genes by long-distance differential display. Anal Biochem. 1998 Jun 1;259(2):235-44
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185432 Umasankar PK, et al., Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol. 2012 May;14(5):488-501
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:201438 Marcello E, et al., Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest. 2013 Jun 3;123(6):2523-38
J:206083 Montagnac G, et al., alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature. 2013 Oct 24;502(7472):567-70
J:230366 Brett TJ, et al., Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure. 2002 Jun;10(6):797-809
J:230398 Traub LM, et al., Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12
J:255150 Piccini A, et al., APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19;21(12):3596-3611
J:256610 Chang HF, et al., Cytotoxic granule endocytosis depends on the Flower protein. J Cell Biol. 2018 Feb 5;217(2):667-683
J:289084 Kawasaki T, et al., Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha. Biochem J. 2008 Jan 15;409(2):471-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343380 Scheele U, et al., Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex. J Biol Chem. 2001 Sep 28;276(39):36131-8