Sequence Detail

ID/Version

P17564 Q3U3L5 Q8C579 Q3TJS6 (UniProt | EBI)

Last sequence update: 1990-08-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein phosphatase 1 regulatory subunit 15A;AltName: Full=Growth arrest and DNA damage-inducible protein GADD34;AltName: Full=Myeloid differentiation primary response protein MyD116;

Provider

SWISS-PROT

Sequence

Polypeptide 657 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp1r15a	protein phosphatase 1, regulatory subunit 15A	34	105	3	12

Sequence references in MGI

J:43397 Zhan Q, et al., The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol. 1994 Apr;14(4):2361-71
J:43409 Lord KA, et al., Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6. Nucleic Acids Res. 1990 May 11;18(9):2823
J:82255 Novoa I, et al., Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 2003 Mar 3;22(5):1180-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106905 Patterson AD, et al., Gadd34 requirement for normal hemoglobin synthesis. Mol Cell Biol. 2006 Mar;26(5):1644-53
J:110590 Kojima E, et al., The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 2003 Aug;17(11):1573-5
J:215662 Novoa I, et al., Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol. 2001 May 28;153(5):1011-22