Sequence Detail

ID/Version

P18654 B1AXN4 Q03140 Q8K3J8 (UniProt | EBI)

Last sequence update: 2003-03-25
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Ribosomal protein S6 kinase alpha-3; Short=S6K-alpha-3; EC=2.7.11.1 {ECO:0000269|PubMed:15109498};AltName: Full=90 kDa ribosomal protein S6 kinase 3; Short=p90-RSK 3; Short=p90RSK3;AltName: Full=MAP kinase-act

Provider

SWISS-PROT

Sequence

Polypeptide 740 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rps6ka3	ribosomal protein S6 kinase polypeptide 3	49	104	4	18

Sequence references in MGI

J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
J:78142 Chrestensen CA, et al., Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase. J Biol Chem. 2002 Aug 2;277(31):27733-41
J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
J:126340 Zaru R, et al., The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007 Nov;8(11):1227-35
J:192971 Saha M, et al., RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem J. 2012 Oct 1;447(1):159-66
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89