Sequence Detail

ID/Version

P20029 Q3UFF2 O35642 Q61630 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Endoplasmic reticulum chaperone BiP {ECO:0000305}; EC=3.6.4.10 {ECO:0000250|UniProtKB:P11021};AltName: Full=78 kDa glucose-regulated protein {ECO:0000303|PubMed:7607546}; Short=GRP-78 {ECO:0000303|PubMed:7607546};AltName: Ful

Provider

SWISS-PROT

Sequence

Polypeptide 655 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hspa5	heat shock protein 5	110	163	3	18

Sequence references in MGI

J:10115 Parfett CL, et al., Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs. Gene. 1989 Oct 30;82(2):291-300
J:31864 Kajiwara K, et al., Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996 Feb 27;219(3):795-9
J:32038 Haas IG, et al., cDNA cloning of the immunoglobulin heavy chain binding protein. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2250-4
J:32663 Kozutsumi Y, et al., Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity. J Cell Sci Suppl. 1989;11:115-37
J:36032 Tillman JB, et al., Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore. Gene. 1995 Jun 9;158(2):225-9
J:76352 Shen Y, et al., Identification and Characterization of a Novel Endoplasmic Reticulum (ER) DnaJ Homologue, Which Stimulates ATPase Activity of BiP in Vitro and Is Induced by ER Stress. J Biol Chem. 2002 May 3;277(18):15947-56
J:77390 Dudek J, et al., A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. EMBO J. 2002 Jun 17;21(12):2958-67
J:81369 Cunnea PM, et al., ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem. 2003 Jan 10;278(2):1059-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117281 Timchenko LT, et al., Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. J Biol Chem. 2006 Oct 27;281(43):32806-19
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215393 Yamamoto S, et al., Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43
J:217288 Meunier L, et al., A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell. 2002 Dec;13(12):4456-69
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313853 Watanabe K, et al., ILDR2 stabilization is regulated by its interaction with GRP78. Sci Rep. 2021 Apr 16;11(1):8414
J:341385 Han C, et al., Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. J Cell Physiol. 2011 May;226(5):1186-95