Sequence Detail

ID/Version

P20722 B2RRV6 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bone morphogenetic protein 6; Short=BMP-6;AltName: Full=VG-1-related protein; Short=VGR-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 510 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bmp6	bone morphogenetic protein 6	77	152	3	11

Sequence references in MGI

J:9842 Lyons K, et al., Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8
J:20320 Gitelman SE, et al., Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 1994 Sep;126(6):1595-609
J:38921 Gitelman SE, et al., Structure and sequence of the mouse Bmp6 gene. Mamm Genome. 1997 Mar;8(3):212-4
J:48561 Solloway MJ, et al., Mice lacking Bmp6 function. Dev Genet. 1998;22(4):321-39
J:86665 Laurikkala J, et al., Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol. 2003 Dec 1;264(1):91-105
J:233140 Andriopoulos B Jr, et al., BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009 Apr;41(4):482-7
J:270227 Arezes J, et al., Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018 Oct 4;132(14):1473-1477
J:335613 Wang CY, et al., Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type Ireceptor ALK3. Blood. 2020;135(6):453-456