Sequence Detail

ID/Version

P21275 (UniProt | EBI)

Last sequence update: 1994-02-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Bone morphogenetic protein 4 {ECO:0000312|MGI:MGI:88180}; Short=BMP-4 {ECO:0000312|MGI:MGI:88180};AltName: Full=Bone morphogenetic protein 2B {ECO:0000312|MGI:MGI:88180}; Short=BMP-2B {ECO:0000312|MGI:MGI:88180};Flags: Precur

Provider

SWISS-PROT

Sequence

Polypeptide 408 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bmp4	bone morphogenetic protein 4	315	502	3	38

Sequence references in MGI

J:4969 Kurihara T, et al., Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region. Biochem Biophys Res Commun. 1993 May 14;192(3):1049-56
J:10440 Dickinson ME, et al., Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics. 1990 Mar;6(3):505-20
J:15534 Takaoka K, et al., Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma. Clin Orthop. 1993 Sep;294:344-52
J:29837 Feng JQ, et al., The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor. J Biol Chem. 1995 Nov 24;270(47):28364-73
J:36231 Chen Y, et al., Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
J:53311 Lawson KA, et al., Bmp4 is required for the generation of primordial germ cells in the mouse embryo [see comments]. Genes Dev. 1999 Feb 15;13(4):424-36
J:86665 Laurikkala J, et al., Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol. 2003 Dec 1;264(1):91-105
J:88556 Oka C, et al., HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development. 2004 Mar;131(5):1041-53
J:91306 Tocharus J, et al., Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ. 2004 Jun;46(3):257-74
J:98740 Samad TA, et al., DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Apr 8;280(14):14122-9
J:101046 Babitt JL, et al., Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Aug 19;280(33):29820-7
J:109016 Babitt JL, et al., Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May;38(5):531-9
J:117670 Sudo S, et al., Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 2004 May 28;279(22):23134-41
J:118865 Hens JR, et al., BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development. 2007 Mar;134(6):1221-30
J:123381 Xia Y, et al., Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22;282(25):18129-40
J:237943 Jia S, et al., Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016 Dec 01;420(1):110-119
J:288268 Miwa T, et al., Tsukushi is essential for the development of the inner ear. Mol Brain. 2020 Mar 3;13(1):29
J:338232 She Y, et al., The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. Cells Dev. 2022 Jan 4;169:203763
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:341424 Feng XY, et al., Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. Eur J Oral Sci. 2013 Oct;121(5):412-20