Sequence Detail

ID/Version

P21570 (UniProt | EBI)

Last sequence update: 1991-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Angiogenin {ECO:0000303|PubMed:2222458}; EC=3.1.27.- {ECO:0000269|PubMed:24752898, ECO:0000269|PubMed:33986151};AltName: Full=Angiogenin-1;AltName: Full=Ribonuclease 5; Short=RNase 5;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 145 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ang	angiogenin, ribonuclease, RNase A family, 5	93	98	3	11

Sequence references in MGI

J:4504 Bond MD, et al., Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim Biophys Acta. 1993 Mar 5;1162(1-2):177-86
J:10791 Bond MD, et al., Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990 Sep 28;171(3):988-95
J:144202 Fu H, et al., Stress induces tRNA cleavage by angiogenin in mammalian cells. FEBS Lett. 2009 Jan 22;583(2):437-42
J:223692 Saikia M, et al., Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 2014 Jul;34(13):2450-63
J:236081 Goncalves KA, et al., Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 2016 Aug 11;166(4):894-906
J:252791 Yu W, et al., Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin. Cell. 2017 Nov 02;171(4):849-864.e25
J:314967 Yue T, et al., SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science. 2021 May 14;372(6543)
J:346267 Liu X, et al., Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. Nat Commun. 2021 Mar 23;12(1):1832
J:359752 Bai R, et al., Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis. EMBO J. 2020 Jul 1;39(13):e103325