Sequence Detail

ID/Version

P21981 Q91VG9 Q8C217 Q3TLV2 Q9R1F7 O88901 (UniProt | EBI)

Last sequence update: 2008-03-18
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Protein-glutamine gamma-glutamyltransferase 2 {ECO:0000305}; EC=2.3.2.13 {ECO:0000250|UniProtKB:P21980};AltName: Full=Isopeptidase TGM2 {ECO:0000305}; EC=3.4.-.- {ECO:0000250|UniProtKB:P21980};AltName: Full=Protein-glutamine

Provider

SWISS-PROT

Sequence

Polypeptide 686 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tgm2	transglutaminase 2, C polypeptide	100	119	4	12

Sequence references in MGI

J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
J:31463 Nagy L, et al., Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter. J Biol Chem. 1996 Feb 23;271(8):4355-65
J:54151 D'Amato M, et al., Mapping and sequencing of the murine 'tissue' transglutaminase (Tgm2) gene: absence of mutations in MRLlpr/lpr mice [letter]. Cell Death Differ. 1999 Mar;6(3):216-7
J:55184 Nanda N, et al., Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2). Arch Biochem Biophys. 1999 Jun 1;366(1):151-6
J:67573 De Laurenzi V, et al., Gene disruption of tissue transglutaminase. Mol Cell Biol. 2001 Jan;21(1):148-55
J:78633 Bernassola F, et al., Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB J. 2002 Sep;16(11):1371-8
J:95130 Nanda N, et al., Targeted inactivation of Gh/tissue transglutaminase II. J Biol Chem. 2001 Jun 8;276(23):20673-8
J:98998 Falasca L, et al., Transglutaminase type II Is a key element in the regulation of the anti-inflammatory response elicited by apoptotic cell engulfment. J Immunol. 2005 Jun 1;174(11):7330-40
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109698 Szondy Z, et al., Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7812-7
J:169279 Malorni W, et al., The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis. Cell Death Differ. 2009 Nov;16(11):1480-92
J:175048 Santhanam L, et al., Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circ Res. 2010 Jul 9;107(1):117-25
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319809 Liu B, et al., Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling. Front Pharmacol. 2019;10:1611