Sequence Detail

ID/Version

P22315 Q544X6 (UniProt | EBI)

Last sequence update: 2022-02-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Ferrochelatase, mitochondrial; EC=4.98.1.1;AltName: Full=Heme synthase;AltName: Full=Protoheme ferro-lyase;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 422 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fech	ferrochelatase	56	100	3	7

Sequence references in MGI

J:10830 Taketani S, et al., Molecular cloning, sequencing, and expression of mouse ferrochelatase. J Biol Chem. 1990 Nov 15;265(32):19377-80
J:10979 Brenner DA, et al., Cloning of murine ferrochelatase. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):849-53
J:12757 Boulechfar S, et al., Ferrochelatase structural mutant (Fechm1Pas) in the house mouse. Genomics. 1993 Jun;16(3):645-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:162800 Chen W, et al., Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood. 2010 Jul 29;116(4):628-30
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:236913 Piel RB 3rd, et al., A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Biochemistry. 2016 Sep 20;55(37):5204-17
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304585 Maio N, et al., Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica. 2019 Sep;104(9):1756-1767