Sequence Detail

ID/Version

P22361 E9QP86 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A;AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1;AltName: Full=Transcription factor 1; Short=TCF-1;

Provider

SWISS-PROT

Sequence

Polypeptide 628 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hnf1a	HNF1 homeobox A	108	125	3	16

Sequence references in MGI

J:10901 Kuo CJ, et al., Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9838-42
J:47008 Lee YH, et al., Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol. 1998 May;18(5):3059-68
J:149154 Servitja JM, et al., Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol Cell Biol. 2009 Jun;29(11):2945-59
J:163147 Rose RB, et al., High-resolution structure of the HNF-1alpha dimerization domain. Biochemistry. 2000 Dec 12;39(49):15062-70
J:271712 Zhang T, et al., Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018;8(19):5246-5258
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89