Sequence Detail

ID/Version

P22366 O35916 (UniProt | EBI)

Last sequence update: 2002-03-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Myeloid differentiation primary response protein MyD88;

Provider

SWISS-PROT

Sequence

Polypeptide 296 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Myd88	myeloid differentiation primary response gene 88	168	116	3	37

Sequence references in MGI

J:36886 Lord KA, et al., Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene. 1990 Jul;5(7):1095-7
J:38114 Bonnert TP, et al., The cloning and characterization of human MyD88: A member of an IL-1 receptor related family. FEBS Lett. 1997 JAN 27;402(1):81-84
J:43983 Hardiman G, et al., Genetic structure and chromosomal mapping of MyD88. Genomics. 1997 Oct 15;45(2):332-9
J:47675 Burns K, et al., MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem. 1998 May 15;273(20):12203-9
J:48832 Adachi O, et al., Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998 Jul;9(1):143-50
J:115304 Negishi H, et al., Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15136-41
J:125955 Brandl K, et al., MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med. 2007 Aug 6;204(8):1891-900
J:140719 Babcock AA, et al., Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol. 2008 Nov 1;181(9):6481-90
J:177506 Vaishnava S, et al., The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science. 2011 Oct 14;334(6053):255-8
J:180126 Troutman TD, et al., Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):273-8
J:257326 Zhao Y, et al., OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Mol Cell. 2018 Feb 1;69(3):505-516.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89