Sequence Detail

ID/Version

P22561 A2A402 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Wilms tumor protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 449 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wt1	WT1 transcription factor	132	274	4	28

Sequence references in MGI

J:11004 Buckler AJ, et al., Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol. 1991 Mar;11(3):1707-12
J:88333 Niksic M, et al., The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet. 2004 Feb 15;13(4):463-71
J:90773 Srichai MB, et al., A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J Biol Chem. 2004 Apr 2;279(14):14398-408
J:117185 Kirschner KM, et al., The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene. J Biol Chem. 2006 Oct 20;281(42):31930-9
J:132868 Dame C, et al., Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood. 2006 Jun 1;107(11):4282-90
J:135126 Val P, et al., Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development. 2007 Jun;134(12):2349-58
J:150743 Buaas FW, et al., The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009 Aug 15;18(16):2989-3001
J:156080 Davies RC, et al., WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev. 1998 Oct 15;12(20):3217-25