Sequence Detail

ID/Version

P22893 P11520 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=mRNA decay activator protein ZFP36 {ECO:0000305};AltName: Full=Growth factor-inducible nuclear protein NUP475 {ECO:0000305};AltName: Full=TPA-induced sequence 11 {ECO:0000303|PubMed:2915901};AltName: Full=Tristetraprolin {ECO:0000303|PubMed:

Provider

SWISS-PROT

Sequence

Polypeptide 319 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zfp36	zinc finger protein 36	125	105	3	15

Sequence references in MGI

J:10719 Lai WS, et al., Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J Biol Chem. 1990 Sep 25;265(27):16556-63
J:25750 Taylor GA, et al., Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J Biol Chem. 1995 Jun 2;270(22):13341-7
J:29461 Lai WS, et al., Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. J Biol Chem. 1995 Oct 20;270(42):25266-72
J:31653 DuBois RN, et al., A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem. 1990 Nov 5;265(31):19185-91
J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
J:33986 Taylor GA, et al., A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 1996 May;4(5):445-54
J:34509 Varnum BC, et al., Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene. 1989 Jan;4(1):119-20
J:75684 Phillips RS, et al., Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem. 2002 Mar 29;277(13):11606-13
J:100865 Kedersha N, et al., Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20;169(6):871-84
J:106919 Hitti E, et al., Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol. 2006 Mar;26(6):2399-407
J:106930 Brook M, et al., Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol. 2006 Mar;26(6):2408-18
J:110360 Carballo E, et al., Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood. 2000 Mar 15;95(6):1891-9
J:132823 Sauer I, et al., Interferons limit inflammatory responses by induction of tristetraprolin. Blood. 2006 Jun 15;107(12):4790-7
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:147768 Horner TJ, et al., Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin. Mol Cell Biol. 2009 Apr;29(8):1999-2010
J:161121 Lai WS, et al., Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol. 1999 Jun;19(6):4311-23
J:196260 Sandler H, et al., Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. Nucleic Acids Res. 2011 May;39(10):4373-86
J:200320 Chrestensen CA, et al., MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem. 2004 Mar 12;279(11):10176-84
J:200326 Johnson BA, et al., Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002 May 17;277(20):18029-36
J:200419 Sun L, et al., Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. J Biol Chem. 2007 Feb 9;282(6):3766-77
J:233560 Tan FE, et al., Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1740-8
J:233569 Lin NY, et al., Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci. 2012;8(5):761-77
J:233588 Mahtani KR, et al., Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol. 2001 Oct;21(19):6461-9
J:233592 Carballo E, et al., Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science. 1998 Aug 14;281(5379):1001-5
J:233888 Nowotarski SL, et al., Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Amino Acids. 2016 Oct;48(10):2303-11
J:234003 Hacker C, et al., ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. Growth Factors. 2010 Jun;28(3):178-90
J:235256 Su YL, et al., Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. PLoS One. 2012;7(7):e41313
J:235259 Marchese FP, et al., MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem. 2010 Sep 3;285(36):27590-600
J:235263 Lin NY, et al., Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells. Biochem Biophys Res Commun. 2008 Jan 4;365(1):69-74
J:235264 Lin NY, et al., Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes. FEBS J. 2007 Feb;274(3):867-78
J:235265 Ogilvie RL, et al., Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J Immunol. 2005 Jan 15;174(2):953-61
J:244789 Hausburg MA, et al., Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27;4:e03390