Sequence Detail

ID/Version

P23242 Q544I7 Q8CE05 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Gap junction alpha-1 protein;AltName: Full=Connexin-43; Short=Cx43;AltName: Full=Gap junction 43 kDa heart protein;

Provider

SWISS-PROT

Sequence

Polypeptide 382 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gja1	gap junction protein, alpha 1	249	232	4	68

Sequence references in MGI

J:1099 Hennemann H, et al., Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung. J Cell Biol. 1992 Jun;117(6):1299-310
J:11145 Beyer EC, et al., Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J Biol Chem. 1991 May 5;266(13):7971-4
J:14428 Sullivan R, et al., Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43. Gene. 1993 Aug 25;130(2):191-9
J:33509 Nishi M, et al., Developmental regulation of gap junction gene expression during mouse embryonic development. Dev Biol. 1991 Jul;146(1):117-30
J:73509 Liu XZ, et al., Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness. Hum Mol Genet. 2001 Dec 1;10(25):2945-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114712 Lan Z, et al., Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry. 2005 Feb 22;44(7):2385-96
J:155343 del Castillo FJ, et al., Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. Hum Mol Genet. 2010 Jan 15;19(2):262-75
J:184186 Straub AC, et al., Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):399-407
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:205637 Negoro H, et al., Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. 2012;3:809
J:224741 Gellhaus A, et al., Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J Biol Chem. 2004 Aug 27;279(35):36931-42
J:227218 Sharma P, et al., Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391
J:273516 Laguesse S, et al., Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Front Cell Neurosci. 2017;11:122
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89