Sequence Detail

ID/Version

P23611 (UniProt | EBI)

Last sequence update: 1991-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Interferon regulatory factor 8 {ECO:0000303|PubMed:17579016}; Short=IRF-8 {ECO:0000303|PubMed:17579016};AltName: Full=Interferon consensus sequence-binding protein {ECO:0000303|PubMed:2111015}; Short=ICSBP {ECO:0000303|PubMed

Provider

SWISS-PROT

Sequence

Polypeptide 424 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irf8	interferon regulatory factor 8	70	114	3	17

Sequence references in MGI

J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
J:81126 Aliberti J, et al., Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood. 2003 Jan 1;101(1):305-10
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110873 Tsujimura H, et al., Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol. 2003 Feb 1;170(3):1131-5
J:111485 Schiavoni G, et al., ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med. 2002 Dec 2;196(11):1415-25
J:149427 Kong HJ, et al., Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages. J Immunol. 2007 Jul 1;179(1):26-30
J:188767 Tussiwand R, et al., Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012 Oct 25;490(7421):502-7
J:194543 Baccala R, et al., Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2940-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:303193 Jeong E, et al., Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. FASEB J. 2020 Sep;34(9):12894-12906