Sequence Detail

ID/Version

P23772 (UniProt | EBI)

Last sequence update: 1991-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Trans-acting T-cell-specific transcription factor GATA-3;AltName: Full=GATA-binding factor 3;

Provider

SWISS-PROT

Sequence

Polypeptide 443 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gata3	GATA binding protein 3	224	188	3	28

Sequence references in MGI

J:20800 Ko LJ, et al., Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol. 1991 May;11(5):2778-84
J:168871 Bates DL, et al., Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol. 2008 Sep 19;381(5):1292-306
J:175086 Chen A, et al., c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol. 2011 Aug;31(16):3445-56
J:204781 Jang EJ, et al., Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. J Immunol. 2013 Jun 1;190(11):5764-70
J:245321 Hwang ES, et al., T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005 Jan 21;307(5708):430-3
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319416 Faas M, et al., IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5