Sequence Detail

ID/Version

P23818 (UniProt | EBI)

Last sequence update: 1991-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Glutamate receptor 1 {ECO:0000305}; Short=GluR-1;AltName: Full=AMPA-selective glutamate receptor 1;AltName: Full=GluR-A {ECO:0000250|UniProtKB:P19490};AltName: Full=GluR-K1 {ECO:0000250|UniProtKB:P19490};AltName: Full=Glutamate recep

Provider

SWISS-PROT

Sequence

Polypeptide 907 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	205	122	4	22

Sequence references in MGI

J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
J:84278 Metzler M, et al., Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J. 2003 Jul 1;22(13):3254-66
J:108736 Uchino S, et al., Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem. 2006 May;97(4):1203-14
J:135974 Matsuda S, et al., Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron. 2008 Mar 13;57(5):730-45
J:158601 Kalashnikova E, et al., SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Neuron. 2010 Jan 14;65(1):80-93
J:167716 Kato AS, et al., Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 2010 Dec 22;68(6):1082-96
J:198375 Wang X, et al., Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr;19(4):473-80
J:201438 Marcello E, et al., Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest. 2013 Jun 3;123(6):2523-38
J:257161 Neuille M, et al., LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1768-1778
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292854 Xiao S, et al., Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels. Acta Neuropathol Commun. 2019 Oct 24;7(1):161
J:314561 Vigil FA, et al., Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor. Sci Rep. 2017 Jun 22;7(1):4040
J:347146 Yu J, et al., Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature. 2021 Jun;594(7863):448-453