Sequence Detail

ID/Version

P23950 (UniProt | EBI)

Last sequence update: 1992-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=mRNA decay activator protein ZFP36L1 {ECO:0000305};AltName: Full=Butyrate response factor 1 {ECO:0000250|UniProtKB:Q07352};AltName: Full=TPA-induced sequence 11b {ECO:0000303|PubMed:1996120};AltName: Full=Zinc finger protein 36, C3H1 type-li

Provider

SWISS-PROT

Sequence

Polypeptide 338 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zfp36l1	zinc finger protein 36, C3H type-like 1	108	107	4	15

Sequence references in MGI

J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
J:75684 Phillips RS, et al., Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem. 2002 Mar 29;277(13):11606-13
J:91579 Stumpo DJ, et al., Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Mol Cell Biol. 2004 Jul;24(14):6445-55
J:113396 Bell SE, et al., The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn. 2006 Nov;235(11):3144-55
J:162388 Hodson DJ, et al., Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol. 2010 Aug;11(8):717-24
J:232475 Galloway A, et al., RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. Science. 2016 Apr 22;352(6284):453-9
J:233560 Tan FE, et al., Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1740-8
J:233561 Viengchareun S, et al., Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control. J Am Soc Nephrol. 2014 Oct;25(10):2213-21
J:233569 Lin NY, et al., Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci. 2012;8(5):761-77
J:233578 Duan H, et al., cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. Mol Endocrinol. 2009 Apr;23(4):497-509
J:233580 Busse M, et al., Strong induction of the Tis11B gene in myogenic differentiation. Eur J Cell Biol. 2008 Jan;87(1):31-8
J:244789 Hausburg MA, et al., Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27;4:e03390