Sequence Detail

ID/Version

P25085 O70207 (UniProt | EBI)

Last sequence update: 1992-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interleukin-1 receptor antagonist protein; Short=IL-1RN; Short=IL-1ra; Short=IRAP;AltName: Full=IL1 inhibitor;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 178 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il1rn	interleukin 1 receptor antagonist	46	97	3	12

Sequence references in MGI

J:2341 Shuck ME, et al., Cloning, heterologous expression and characterization of murine interleukin 1 receptor antagonist protein. Eur J Immunol. 1991 Nov;21(11):2775-80
J:11218 Zahedi K, et al., Mouse IL-1 receptor antagonist protein. Molecular characterization, gene mapping, and expression of mRNA in vitro and in vivo. J Immunol. 1991 Jun 15;146(12):4228-33
J:11260 Eisenberg SP, et al., Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5232-6
J:11351 Matsushime H, et al., Cloning and expression of murine interleukin-1 receptor antagonist in macrophages stimulated by colony-stimulating factor 1. Blood. 1991 Aug 1;78(3):616-23
J:28560 Zahedi KA, et al., The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro. Cytokine. 1994 Jan;6(1):1-9
J:44642 Gabay C, et al., Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. J Immunol. 1997 Dec 15;159(12):5905-13
J:293347 Ji DX, et al., Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nat Microbiol. 2019 Dec;4(12):2128-2135
J:325397 Tahtinen S, et al., IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. Nat Immunol. 2022 Apr;23(4):532-542