Sequence Detail

ID/Version

P25911 Q62127 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Tyrosine-protein kinase Lyn; EC=2.7.10.2;AltName: Full=V-yes-1 Yamaguchi sarcoma viral related oncogene homolog;AltName: Full=p53Lyn;AltName: Full=p56Lyn;

Provider

SWISS-PROT

Sequence

Polypeptide 512 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lyn	LYN proto-oncogene, Src family tyrosine kinase	194	102	3	24

Sequence references in MGI

J:11246 Stanley E, et al., Alternatively spliced murine lyn mRNAs encode distinct proteins. Mol Cell Biol. 1991 Jul;11(7):3399-406
J:17868 Clark MR, et al., Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J. 1994 Apr 15;13(8):1911-9
J:19809 Yi TL, et al., Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol. 1991 May;11(5):2391-8
J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
J:29356 Hibbs ML, et al., Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 1995 Oct 20;83(2):301-11
J:29751 Nishizumi H, et al., Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 1995 Nov;3(5):549-60
J:35280 Wang J, et al., Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med. 1996 Sep 1;184(3):831-8
J:42037 Chan VW, et al., Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul;7(1):69-81
J:70417 O'Laughlin-Bunner B, et al., Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15;98(2):343-50
J:72269 Harder KW, et al., Gain- and loss-of-function lyn mutant mice define a critical inhibitory role for lyn in the myeloid lineage. Immunity. 2001 Oct;15(4):603-15
J:82731 Fujii Y, et al., Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 2003 Apr 10;540(1-3):111-6
J:87475 Hernandez-Hansen V, et al., The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol. 2004 Jan;75(1):143-51
J:90545 Lannutti BJ, et al., Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood. 2004 May 15;103(10):3736-43
J:95641 Yamanashi Y, et al., Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev. 2000 Jan 1;14(1):11-6
J:96277 Xu Y, et al., Lyn tyrosine kinase; accentuating the positive and the negative. Immunity. 2005 Jan;22(1):9-18
J:107272 Beavitt SJ, et al., Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol. 2005 Aug 1;175(3):1867-75
J:110687 Nishizumi H, et al., Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol. 1997 Mar 1;158(5):2350-5
J:110913 Hibbs ML, et al., Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med. 2002 Dec 16;196(12):1593-604
J:110932 Nishizumi H, et al., A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med. 1998 Apr 20;187(8):1343-8
J:111097 Smith KG, et al., Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med. 1998 Mar 2;187(5):807-11
J:113243 Chu CL, et al., The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol. 2005 Sep 1;175(5):2880-9
J:116450 Udell CM, et al., Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. J Biol Chem. 2006 Jul 28;281(30):20949-57
J:119327 Shao Y, et al., Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl. J Biol Chem. 2004 Oct 15;279(42):43646-53
J:119693 Xiao W, et al., Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 2005 Nov 15;175(10):6885-92
J:121675 Rathore VB, et al., Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J. 2007 Apr 15;403(2):275-81
J:124931 Chew V, et al., Leupaxin negatively regulates B cell receptor signaling. J Biol Chem. 2007 Sep 14;282(37):27181-91
J:129312 Ahn E, et al., LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood. 2006 Feb 15;107(4):1521-7
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:146423 Chan VW, et al., Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 7;8(10):545-53
J:148303 Samuels AL, et al., Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood. 2009 Apr 16;113(16):3845-56
J:161005 Keck S, et al., Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol. 2010 May 15;184(10):5809-18
J:178285 Ochi H, et al., Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Immunology. 1999 Dec;98(4):595-603
J:178287 Pleiman CM, et al., Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science. 1994 Mar 18;263(5153):1609-12
J:178438 Li Z, et al., An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23;285(17):12559-70
J:195394 Lu R, et al., CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8(4):e1002597
J:244275 Luo L, et al., SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 2017 Jan 18;8:14133
J:266145 Rawlings DJ, et al., Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 1996 Feb 9;271(5250):822-5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354149 Adachi T, et al., The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 1998 May 15;160(10):4662-5