Sequence Detail

ID/Version

P26039 Q8VEF0 A2AIM8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Talin-1;

Provider

SWISS-PROT

Sequence

Polypeptide 2541 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tln1	talin 1	40	104	3	89

Sequence references in MGI

J:43417 Rees DJ, et al., Sequence and domain structure of talin. Nature. 1990 Oct 18;347(6294):685-9
J:116247 Papagrigoriou E, et al., Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J. 2004 Aug 4;23(15):2942-51
J:175678 Brunner M, et al., Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011 Jul 25;194(2):307-22
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:203509 Goult BT, et al., RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem. 2013 Mar 22;288(12):8238-49
J:240268 Gingras AR, et al., Central region of talin has a unique fold that binds vinculin and actin. J Biol Chem. 2010 Sep 17;285(38):29577-87
J:247412 Fillingham I, et al., A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head. Structure. 2005 Jan;13(1):65-74
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333810 Elenbaas JS, et al., SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Nat Commun. 2023 Feb 15;14(1):850