Sequence Detail

ID/Version

P26231 (UniProt | EBI)

Last sequence update: 1992-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Catenin alpha-1 {ECO:0000312|MGI:MGI:88274};AltName: Full=102 kDa cadherin-associated protein {ECO:0000303|PubMed:1904011}; Short=CAP102 {ECO:0000303|PubMed:1904011};AltName: Full=Alpha E-catenin {ECO:0000312|MGI:MGI:88274};

Provider

SWISS-PROT

Sequence

Polypeptide 906 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ctnna1	catenin alpha 1	84	117	3	157

Sequence references in MGI

J:16351 Herrenknecht K, et al., The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9156-60
J:16355 Nagafuchi A, et al., The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell. 1991 May 31;65(5):849-57
J:37378 Butz S, et al., Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. FEBS Lett. 1994 Nov 28;355(2):195-200
J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
J:61504 Pokutta S, et al., Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell. 2000 Mar;5(3):533-43
J:169049 Varelas X, et al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44
J:227177 Saksens NT, et al., Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity. Nat Genet. 2016 Feb;48(2):144-51
J:248258 Abe K, et al., EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):13-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89