Sequence Detail

ID/Version

P27005 P31724 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein S100-A8 {ECO:0000305};AltName: Full=Calgranulin-A;AltName: Full=Chemotactic cytokine CP-10;AltName: Full=Leukocyte L1 complex light chain;AltName: Full=Migration inhibitory factor-related protein 8; Short=MRP-8; Short

Provider

SWISS-PROT

Sequence

Polypeptide 89 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	S100a8	S100 calcium binding protein A8 (calgranulin A)	44	104	2	15

Sequence references in MGI

J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
J:17391 Lackmann M, et al., Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10. J Immunol. 1993 Apr 1;150(7):2981-91
J:31265 Nacken W, et al., Molecular characterisation of the genomic locus of the mouse MRP8 gene. Biochim Biophys Acta. 1996 Jan 17;1315(1):1-5
J:56750 Passey RJ, et al., A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol. 1999 Aug 15;163(4):2209-16
J:125179 Vogl T, et al., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007 Sep;13(9):1042-9
J:140757 Lim SY, et al., S-nitrosylated S100A8: novel anti-inflammatory properties. J Immunol. 2008 Oct 15;181(8):5627-36
J:149024 Boyd JH, et al., S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 2008 May 23;102(10):1239-46
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:308901 Guo Q, et al., Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4