Sequence Detail

ID/Version

P27545 (UniProt | EBI)

Last sequence update: 1992-08-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Ceramide synthase 1 {ECO:0000303|PubMed:17977534}; Short=CerS1 {ECO:0000303|PubMed:17977534};AltName: Full=Longevity assurance gene 1 protein homolog 1 {ECO:0000303|PubMed:15823095};AltName: Full=Protein UOG-1 {ECO:0000303|PubMed:203

Provider

SWISS-PROT

Sequence

Polypeptide 350 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cers1	ceramide synthase 1	21	98	3	9

Sequence references in MGI

J:11181 Lee SJ, Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4250-4
J:117381 Spassieva S, et al., Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem. 2006 Nov 10;281(45):33931-8
J:117553 Mizutani Y, et al., Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71
J:127737 Lahiri S, et al., Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett. 2007 Nov 13;581(27):5289-94
J:172719 Zhao L, et al., A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May;7(5):e1002063
J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73
J:284081 Turpin-Nolan SM, et al., CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep. 2019 Jan 2;26(1):1-10.e7