Sequence Detail

ID/Version

P27661 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Histone H2AX; Short=H2a/x;AltName: Full=Histone H2A.X;

Provider

SWISS-PROT

Sequence

Polypeptide 143 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	H2ax	H2A.X variant histone	57	182	3	8

Sequence references in MGI

J:11221 Nagata T, et al., Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. Nucleic Acids Res. 1991 May 11;19(9):2441-7
J:22825 Porcher C, et al., Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis. Genomics. 1995 Jan 1;25(1):312-3
J:73342 Petersen S, et al., AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001 Dec 6;414(6864):660-5
J:76360 Celeste A, et al., Genomic instability in mice lacking histone H2AX. Science. 2002 May 3;296(5569):922-7
J:84879 Bassing CH, et al., Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 2003 Aug 8;114(3):359-70
J:84909 Bassing CH, et al., Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8
J:86590 Celeste A, et al., H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell. 2003 Aug 8;114(3):371-83
J:95016 Turner JM, et al., BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol. 2004 Dec 14;14(23):2135-42
J:96007 Kang J, et al., Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol. 2005 Jan;25(2):661-70
J:109017 Fernandez-Capetillo O, et al., H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell. 2003 Apr;4(4):497-508
J:126641 Mahadevaiah SK, et al., Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet. 2001 Mar;27(3):271-6
J:143888 Xiao A, et al., WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 2009 Jan 1;457(7225):57-62
J:192634 Kogo H, et al., HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012 Nov;17(11):897-912
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:268520 Zhang Q, et al., Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. Commun Biol. 2018;1:147
J:285969 Liu H, et al., SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res. 2019 Jun 20;47(11):5670-5683
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297328 Zhang Q, et al., SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019 Jan;5(1):eaau9780
J:341403 Burma S, et al., ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem. 2001 Nov 9;276(45):42462-7