Sequence Detail

ID/Version

P28063 Q7TMX9 Q91VH7 Q792S8 Q3UK42 Q64300 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Proteasome subunit beta type-8; EC=3.4.25.1;AltName: Full=Low molecular mass protein 7;AltName: Full=Macropain subunit C13;AltName: Full=Multicatalytic endopeptidase complex subunit C13;AltName: Full=Proteasome component C13;AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 276 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	16	97	3	9

Sequence references in MGI

J:954 Frentzel S, et al., Isolation and characterization of the MHC linked beta-type proteasome subunit MC13 cDNA. FEBS Lett. 1992 May 11;302(2):121-5
J:15540 Zanelli E, et al., Genomic organization and tissue expression of the mouse proteasome gene Lmp-7. Immunogenetics. 1993;38(6):400-7
J:16093 Meinhardt T, et al., Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes. Immunogenetics. 1993;38(5):373-9
J:20012 Fehling HJ, et al., MHC class I expression in mice lacking the proteasome subunit LMP-7. Science. 1994 Aug 26;265(5176):1234-7
J:35211 Nandi D, et al., Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7. Exp Clin Immunogenet. 1996;13(1):20-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:151526 Muchamuel T, et al., A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med. 2009 Jul;15(7):781-7
J:177396 Kitamura A, et al., A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans. J Clin Invest. 2011 Oct 3;121(10):4150-60
J:181547 Huber EM, et al., Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell. 2012 Feb 17;148(4):727-38
J:188902 Gomes AV, et al., Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006 Aug 18;99(4):362-71
J:197675 Qian MX, et al., Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May 23;153(5):1012-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89