Sequence Detail

ID/Version

P28661 Q3UVH1 Q80VX1 Q7TPM7 B2KGM3 B2KGM6 Q3UZC3 Q5ND10 Q5ND15 Q5ND16 Q5ND19 (UniProt | EBI)

Last sequence update: 1992-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Septin-4 {ECO:0000312|MGI:MGI:1270156};AltName: Full=Bradeion beta {ECO:0000250|UniProtKB:O43236};AltName: Full=Brain protein H5 {ECO:0000303|PubMed:12581152};AltName: Full=CE5B3 beta {ECO:0000250|UniProtKB:O43236};AltName: Full=Cell divisio

Provider

SWISS-PROT

Sequence

Polypeptide 478 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Septin4	septin 4	57	106	5	8

Sequence references in MGI

J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
J:96669 Kissel H, et al., The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005 Mar;8(3):353-64
J:96670 Ihara M, et al., Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell. 2005 Mar;8(3):343-52
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136786 Ihara M, et al., Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33
J:144655 Sitz JH, et al., The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. Neuroscience. 2008 Dec 2;157(3):596-605
J:165092 Garcia-Fernandez M, et al., Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev. 2010 Oct 15;24(20):2282-93
J:198601 Kim JB, et al., Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J Biol Chem. 2013 Apr 26;288(17):12014-21
J:199466 Fuchs Y, et al., Sept4/ARTS regulates stem cell apoptosis and skin regeneration. Science. 2013 Jul 19;341(6143):286-9
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:269496 Koren E, et al., ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat Commun. 2018 Nov 2;9(1):4582
J:277914 Maruyama SY, et al., A critical role of solute carrier 22a14 in sperm motility and male fertility in mice. Sci Rep. 2016 Nov 4;6:36468
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306638 Shinoda T, et al., Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Mol Biol Cell. 2010 Apr 15;21(8):1324-34