Sequence Detail

ID/Version

P31266 Q8C4Z3 Q80UN8 (UniProt | EBI)

Last sequence update: 1993-07-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Recombining binding protein suppressor of hairless;AltName: Full=J kappa-recombination signal-binding protein;AltName: Full=RBP-J kappa;

Provider

SWISS-PROT

Sequence

Polypeptide 526 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rbpj	recombination signal binding protein for immunoglobulin kappa J region	139	121	5	276

Sequence references in MGI

J:609 Hamaguchi Y, et al., Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes. Adv Exp Med Biol. 1991;292:177-86
J:2281 Kawaichi M, et al., Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. J Biol Chem. 1992 Feb 25;267(6):4016-22
J:14449 Matsunami N, et al., A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature. 1989 Dec 21-28;342(6252):934-7
J:28945 Jarriault S, et al., Signalling downstream of activated mammalian Notch [see comments]. Nature. 1995 Sep 28;377(6547):355-8
J:49913 Taniguchi Y, et al., LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein. Mol Cell Biol. 1998 Jan;18(1):644-54
J:62777 Obata J, et al., p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells. 2001 Apr;6(4):345-60
J:64684 Kao HY, et al., Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000 Jan 1;14(1):55-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121406 Ma X, et al., Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Mol Cell Biol. 2007 Apr;27(8):3056-64
J:137568 Friedmann DR, et al., RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. J Biol Chem. 2008 May 23;283(21):14781-91
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:224449 Graham DB, et al., Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst. Nat Commun. 2015;6:7838
J:229252 Okuda H, et al., A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. PLoS One. 2015;10(4):e0124293
J:331358 Xu T, et al., RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J. 2017 Nov 2;36(21):3232-3249