Sequence Detail

ID/Version

P31750 Q62274 Q6GSA6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=RAC-alpha serine/threonine-protein kinase; EC=2.7.11.1 {ECO:0000269|PubMed:22057101, ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:30504268};AltName: Full=AKT1 kinase;AltName: Full=Protein kinase B; Short=PKB;AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 480 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akt1	thymoma viral proto-oncogene 1	323	239	3	35

Sequence references in MGI

J:3973 Bellacosa A, et al., Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 1993 Mar;8(3):745-54
J:79113 Xu J, et al., The role of Asp-462 in regulating Akt activity. J Biol Chem. 2002 Sep 20;277(38):35561-6
J:85181 Yang ZZ, et al., Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31
J:98784 Urschel S, et al., Phosphorylation of grb10 regulates its interaction with 14-3-3. J Biol Chem. 2005 Apr 29;280(17):16987-93
J:99088 Anai M, et al., A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005 May 6;280(18):18525-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113828 Cong LN, et al., Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol. 1997 Dec;11(13):1881-90
J:114062 Yamashita K, et al., Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ Res. 2001 Mar 30;88(6):609-14
J:135467 Kitamura T, et al., Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol. 1999 Sep;19(9):6286-96
J:154919 Kim JY, et al., DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009 Sep 24;63(6):761-73
J:157003 Rodgers JT, et al., Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan;11(1):23-34
J:158889 Mahajan K, et al., Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One. 2010;5(3):e9646
J:167176 Oh WJ, et al., mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010 Dec 1;29(23):3939-51
J:180612 Wakatsuki S, et al., ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol. 2011 Dec;13(12):1415-23
J:213891 Nawa M, et al., KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013;14:27
J:213903 Nawa M, et al., A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008 Mar;20(3):493-505
J:224547 Man SM, et al., Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell. 2015 Jul 2;162(1):45-58
J:225409 Fritzius T, et al., A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J. 2006 Oct 1;399(1):9-20
J:225490 Fritzius T, et al., Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 2008 May 7;27(9):1399-410
J:228671 Wilson JE, et al., Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med. 2015 Aug;21(8):906-13
J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714
J:255333 Yao Y, et al., BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal. 2013 Jan 8;6(257):ra2
J:260006 Mounir Z, et al., Akt determines cell fate through inhibition of the PERK-eIF2alpha phosphorylation pathway. Sci Signal. 2011 Sep 27;4(192):ra62
J:261835 Virtanen C, et al., Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. J Biol Chem. 2009 Jan 16;284(3):1636-43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:293308 Lammert CR, et al., AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature. 2020 Apr;580(7805):647-652
J:347326 Marchi S, et al., Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth. EMBO J. 2019 Jan 15;38(2)