Sequence Detail

ID/Version

P35329 Q9JJY0 Q9R094 Q9JHL2 Q9JJX9 Q3UP36 Q9R056 Q9WU51 Q9JJY1 (UniProt | EBI)

Last sequence update: 2022-02-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=B-cell receptor CD22 {ECO:0000305};AltName: Full=B-lymphocyte cell adhesion molecule; Short=BL-CAM;AltName: Full=Sialic acid-binding Ig-like lectin 2; Short=Siglec-2;AltName: Full=T-cell surface antigen Leu-14;AltName: CD_ant

Provider

SWISS-PROT

Sequence

Polypeptide 868 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd22	CD22 antigen	36	99	3	31

Sequence references in MGI

J:13270 Law CL, et al., Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles. J Immunol. 1993 Jul 1;151(1):175-87
J:38644 Nitschke L, et al., CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997 Feb 1;7(2):133-43
J:57638 Lajaunias F, et al., Polymorphisms in the Cd22 gene of inbred mouse strains. Immunogenetics. 1999 Oct;49(11-12):991-5
J:64573 Mary C, et al., Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol. 2000 Sep 15;165(6):2987-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113920 Poe JC, et al., CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem. 2000 Jun 9;275(23):17420-7
J:116377 Yohannan J, et al., Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J Biol Chem. 1999 Jun 25;274(26):18769-76
J:146423 Chan VW, et al., Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 7;8(10):545-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89