Sequence Detail

ID/Version

P35428 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Transcription factor HES-1;AltName: Full=Hairy and enhancer of split 1;

Provider

SWISS-PROT

Sequence

Polypeptide 282 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hes1	hes family bHLH transcription factor 1	209	213	3	18

Sequence references in MGI

J:16921 Takebayashi K, et al., Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J Biol Chem. 1994 Feb 18;269(7):5150-6
J:51674 Grbavec D, et al., Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Eur J Biochem. 1998 Dec 1;258(2):339-49
J:62626 Bae S, et al., The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development. 2000 Jul;127(13):2933-43