Sequence Detail

ID/Version

P35441 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Thrombospondin-1;AltName: Full=Glycoprotein G {ECO:0000250|UniProtKB:P07996};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1170 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Thbs1	thrombospondin 1	109	122	4	14

Sequence references in MGI

J:1991 Laherty CD, et al., Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development. J Biol Chem. 1992 Feb 15;267(5):3274-81
J:10721 Bornstein P, et al., Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression. J Biol Chem. 1990 Sep 25;265(27):16691-8
J:11580 Lawler J, et al., Characterization of the murine thrombospondin gene. Genomics. 1991 Nov;11(3):587-600
J:33432 Chen H, et al., Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. FEBS Lett. 1996 May 27;387(1):36-41
J:183150 Bauer EM, et al., Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation. Cardiovasc Res. 2010 Dec 1;88(3):471-81
J:186160 Lynch JM, et al., A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012 Jun 8;149(6):1257-68
J:203200 Kong P, et al., Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E439-50
J:230545 Cui W, et al., Interaction of thrombospondin1 and CD36 contributes to obesity-associated podocytopathy. Biochim Biophys Acta. 2015 Jul;1852(7):1323-33
J:253371 Rogers NM, et al., TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. Cardiovasc Res. 2017 Jan;113(1):15-29
J:259049 Meijles DN, et al., The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Sci Signal. 2017 Oct 17;10(501)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304492 Ghimire K, et al., CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. Cells. 2020 Jul 15;9(7):1695