Sequence Detail

ID/Version

P35639 Q91YW9 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DNA damage-inducible transcript 3 protein; Short=DDIT-3;AltName: Full=C/EBP zeta;AltName: Full=C/EBP-homologous protein {ECO:0000303|PubMed:21285359}; Short=CHOP {ECO:0000303|PubMed:21285359};AltName: Full=C/EBP-homologous pr

Provider

SWISS-PROT

Sequence

Polypeptide 168 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddit3	DNA-damage inducible transcript 3	153	33	3	23

Sequence references in MGI

J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
J:95320 Marciniak SJ, et al., CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004 Dec 15;18(24):3066-77
J:131780 Endo M, et al., C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol. 2006 May 15;176(10):6245-53
J:153833 Li G, et al., Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol. 2009 Sep 21;186(6):783-92
J:167725 Galehdar Z, et al., Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010 Dec 15;30(50):16938-48
J:189996 Ohoka N, et al., TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 2005 Mar 23;24(6):1243-55
J:190262 Loinard C, et al., C/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization through control of endothelial nitric oxide synthase gene expression. Circulation. 2012 Feb 28;125(8):1014-26
J:190264 Alter J, et al., Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. PLoS One. 2011;6(12):e29498
J:198492 Han J, et al., ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013 May;15(5):481-90