Sequence Detail

ID/Version

P37172 Q91VF1 Q3UDH5 (UniProt | EBI)

Last sequence update: 2006-10-17
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Activin receptor type-1; EC=2.7.11.30;AltName: Full=Activin receptor type I; Short=ACTR-I;AltName: Full=Serine/threonine-protein kinase receptor R1; Short=SKR1;AltName: Full=TGF-B superfamily receptor type I;

Provider

SWISS-PROT

Sequence

Polypeptide 509 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Acvr1	activin A receptor, type 1	119	129	3	28

Sequence references in MGI

J:25557 Ebner R, et al., Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science. 1993 May 28;260(5112):1344-8
J:57670 Mishina Y, et al., Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol. 1999 Sep 15;213(2):314-26
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:95020 Kishigami S, et al., BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev Biol. 2004 Dec 1;276(1):185-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:178480 Kamiya N, et al., Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. Biochem Biophys Res Commun. 2011 Oct 22;414(2):326-30
J:233359 Rigueur D, et al., The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015 Apr;30(4):733-41
J:335613 Wang CY, et al., Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type Ireceptor ALK3. Blood. 2020;135(6):453-456