Sequence Detail

ID/Version

P39688 Q8K2A3 Q3TAT3 Q3U0T5 (UniProt | EBI)

Last sequence update: 2013-04-03
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Tyrosine-protein kinase Fyn; EC=2.7.10.2 {ECO:0000269|PubMed:12526739, ECO:0000269|PubMed:12681493};AltName: Full=Proto-oncogene c-Fyn;AltName: Full=p59-Fyn;

Provider

SWISS-PROT

Sequence

Polypeptide 537 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fyn	Fyn proto-oncogene	165	121	4	23

Sequence references in MGI

J:3417 Grant SG, et al., Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice [see comments]. Science. 1992 Dec 18;258(5090):1903-10
J:17868 Clark MR, et al., Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J. 1994 Apr 15;13(8):1911-9
J:37401 Cooke MP, et al., Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol. 1989 Oct;1(1):66-74
J:73962 Seykora JT, et al., 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem. 2002 Jan 25;277(4):2812-22
J:82731 Fujii Y, et al., Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 2003 Apr 10;540(1-3):111-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109820 Arnaud L, et al., Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003 Jan 8;13(1):9-17
J:112254 Yasuda K, et al., Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol. 2002 Sep 15;169(6):2813-7
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161749 Mill P, et al., Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet. 2009 Nov;5(11):e1000748
J:169648 Murata Y, et al., Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells. 2010 May;15(5):513-24
J:176593 Babus LW, et al., Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res. 2011 Sep 30;1415:96-102
J:269564 Purohit AA, et al., Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J Biol Chem. 2012 Aug 3;287(32):27126-38
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89