Sequence Detail

ID/Version

P39689 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Cyclin-dependent kinase inhibitor 1;AltName: Full=CDK-interacting protein 1;AltName: Full=Melanoma differentiation-associated protein;AltName: Full=p21;

Provider

SWISS-PROT

Sequence

Polypeptide 159 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdkn1a	cyclin dependent kinase inhibitor 1A	124	253	3	42

Sequence references in MGI

J:20546 Huppi K, et al., Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1). Oncogene. 1994 Oct;9(10):3017-20
J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
J:160788 Li Z, et al., An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 6;29(18):2659-71
J:217430 Esteve-Puig R, et al., A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct;10(10):e1004721
J:336734 Saito A, et al., p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS. Cell Rep. 2023 May 30;42(5):112479
J:352393 Muller L, et al., Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling. Cell Rep. 2023 Jan 31;42(1):112031