Sequence Detail

ID/Version

P40240 Q3U9W0 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=CD9 antigen {ECO:0000303|PubMed:8236164};AltName: CD_antigen=CD9 {ECO:0000303|PubMed:8236164};

Provider

SWISS-PROT

Sequence

Polypeptide 226 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd9	CD9 antigen	40	110	4	189

Sequence references in MGI

J:15493 Rubinstein E, et al., Molecular cloning of the mouse equivalent of CD9 antigen. Thromb Res. 1993 Sep 1;71(5):377-83
J:59401 Le Naour F, et al., Severely reduced female fertility in CD9-deficient mice. Science. 2000 Jan 14;287(5451):319-21
J:59402 Miyado K, et al., Requirement of CD9 on the egg plasma membrane for fertilization. Science. 2000 Jan 14;287(5451):321-4
J:60753 Kaji K, et al., The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000 Mar;24(3):279-82
J:76223 Waterhouse R, et al., Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. J Exp Med. 2002 Jan 21;195(2):277-82
J:83795 Takeda Y, et al., Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol. 2003 Jun 9;161(5):945-56
J:87762 Ishibashi T, et al., Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J Neurosci. 2004 Jan 7;24(1):96-102
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141975 Takeda Y, et al., Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. J Biol Chem. 2008 Sep 19;283(38):26089-97
J:174304 Jegou A, et al., CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilization. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):10946-51
J:185340 Ohnami N, et al., CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. Biol Open. 2012 Jul 15;1(7):640-7
J:271693 Charrin S, et al., Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun. 2013;4:1674
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:359376 Chalbi M, et al., Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization. Development. 2014 Oct;141(19):3732-9
J:360890 Zhu GZ, et al., Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion. Development. 2002 Apr;129(8):1995-2002