Sequence Detail

ID/Version

P40694 (UniProt | EBI)

Last sequence update: 1995-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DNA-binding protein SMUBP-2 {ECO:0000303|PubMed:8493094}; EC=3.6.4.12 {ECO:0000250|UniProtKB:P38935}; EC=3.6.4.13 {ECO:0000305|PubMed:22965130};AltName: Full=ATP-dependent helicase IGHMBP2;AltName: Full=Cardiac transcription

Provider

SWISS-PROT

Sequence

Polypeptide 993 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ighmbp2	immunoglobulin mu DNA binding protein 2	61	106	3	19

Sequence references in MGI

J:4973 Mizuta TR, et al., Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences. Nucleic Acids Res. 1993 Apr 25;21(8):1761-6
J:146154 Guenther UP, et al., IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Hum Mol Genet. 2009 Apr 1;18(7):1288-300
J:148546 de Planell-Saguer M, et al., Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. Hum Mol Genet. 2009 Jun 15;18(12):2115-26
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314557 Lim SC, et al., The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1. Nucleic Acids Res. 2012 Nov;40(21):11009-22