Sequence Detail

ID/Version

P41136 O88604 (UniProt | EBI)

Last sequence update: 2000-05-30
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=DNA-binding protein inhibitor ID-2;AltName: Full=Inhibitor of DNA binding 2;AltName: Full=Inhibitor of differentiation 2;

Provider

SWISS-PROT

Sequence

Polypeptide 134 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Id2	inhibitor of DNA binding 2	103	171	4	24

Sequence references in MGI

J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
J:51406 Mantani A, et al., The mouse Id2 and Id4 genes: structural organization and chromosomal localization. Gene. 1998 Nov 19;222(2):229-35
J:96909 Kurooka H, et al., Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors. J Biol Chem. 2005 Feb 11;280(6):4313-20
J:113476 Ding B, et al., p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins. J Biol Chem. 2006 May 26;281(21):14893-906
J:146624 Duffield GE, et al., A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol. 2009 Feb 24;19(4):297-304
J:156337 Hou TY, et al., ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J Biol Chem. 2009 Nov 13;284(46):31735-45
J:211243 Ward SM, et al., The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010 Dec 10;285(50):38987-9000
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89