Sequence Detail

ID/Version

P41438 Q62451 Q62450 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Reduced folate transporter {ECO:0000305};AltName: Full=Intestinal folate carrier 1 {ECO:0000303|PubMed:8664315}; Short=IFC-1 {ECO:0000303|PubMed:8664315};AltName: Full=Plasma membrane folate antiporter SLC19A1 {ECO:0000305};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 512 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc19a1	solute carrier family 19 (folate transporter), member 1	49	105	3	20

Sequence references in MGI

J:16454 Dixon KH, et al., A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem. 1994 Jan 7;269(1):17-20
J:29055 Brigle KE, et al., Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. J Biol Chem. 1995 Sep 29;270(39):22974-9
J:33486 Said HM, et al., Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochim Biophys Acta. 1996 Jun 11;1281(2):164-72
J:39774 Chiao JH, et al., RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem. 1997 Apr 25;272(17):11165-70
J:40074 Tolner B, et al., Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter. Gene. 1997 Apr 11;189(1):1-7
J:50354 Tse A, et al., Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate. J Biol Chem. 1998 Oct 2;273(40):25953-60
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:222686 Chancy CD, et al., Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem. 2000 Jul 7;275(27):20676-84
J:279972 Luteijn RD, et al., SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019 Sep;573(7774):434-438
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89