Sequence Detail

ID/Version

P42227 B7ZC17 A2A5D1 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Signal transducer and activator of transcription 3 {ECO:0000312|MGI:MGI:103038};AltName: Full=Acute-phase response factor {ECO:0000303|PubMed:7512451, ECO:0000303|PubMed:7523373};

Provider

SWISS-PROT

Sequence

Polypeptide 770 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stat3	signal transducer and activator of transcription 3	245	153	3	76

Sequence references in MGI

J:29556 Zhong Z, et al., Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994 Apr 1;264(5155):95-8
J:29557 Akira S, et al., Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 1994 Apr 8;77(1):63-71
J:37233 Schaefer TS, et al., Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9097-101
J:40106 Takeda K, et al., Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4
J:48717 Becker S, et al., Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51
J:52872 Chung CD, et al., Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5
J:64303 Collum RG, et al., A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10120-5
J:67577 Miyoshi K, et al., Structure of the mouse stat 3/5 locus: evolution from drosophila to zebrafish to mouse. Genomics. 2001 Jan 15;71(2):150-5
J:70439 Raz R, et al., Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J Biol Chem. 1994 Sep 30;269(39):24391-5
J:82334 Bates SH, et al., STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003 Feb 20;421(6925):856-9
J:99729 Liu L, et al., STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8150-5
J:131811 Muromoto R, et al., BART is essential for nuclear retention of STAT3. Int Immunol. 2008 Mar;20(3):395-403
J:136071 Fox DL, et al., Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3. Mol Endocrinol. 2008 Jun;22(6):1438-48
J:148070 Ohkawara B, et al., Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 2004 Feb 15;18(4):381-6
J:159996 Kostromina E, et al., Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. Endocrinology. 2010 May;151(5):2050-9
J:194021 Shen S, et al., Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell. 2012 Dec 14;48(5):667-80
J:196462 Choi SM, et al., Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. J Exp Med. 2013 Mar 11;210(3):551-61
J:223391 Ren F, et al., Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. FEBS Lett. 2015 Jul 8;589(15):1890-6
J:227387 Gonzalez RR, et al., Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem. 2006 Sep 8;281(36):26320-8
J:243387 Sinha A, et al., Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency. Cell Rep. 2013 Aug 29;4(4):649-58
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:334173 Jeon YJ, et al., Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. J Biol Chem. 2010 Sep 3;285(36):28126-33
J:343388 Manukyan I, et al., Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. J Cell Mol Med. 2010 Jun;14(6B):1707-16
J:354403 Ren F, et al., SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. Cell Signal. 2013 Nov;25(11):2272-80