Sequence Detail

ID/Version

P42866 Q4U2P4 Q9R0D1 Q9R1L9 A1YAC3 Q8CAN5 Q4U2Q6 Q6YC50 Q8CH75 Q9R1M0 Q8VI69 Q548C6 Q8VI71 Q8CGW2 Q9JIY1 Q8CH74 Q8VI70 Q8VIP0 A5H7G2 Q8VBX8 Q8CH73 Q8VIN5 Q60768 Q8VBU6 Q8VIP1 Q8VIN3 A1YAC4 Q8VBU3 Q8VIN6 A1XGX3 A1XGX4 Q8VIN4 (UniProt | EBI)

Last sequence update: 1995-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Mu-type opioid receptor; Short=M-OR-1; Short=MOR-1;

Provider

SWISS-PROT

Sequence

Polypeptide 398 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Oprm1	opioid receptor, mu 1	92	120	3	47

Sequence references in MGI

J:20441 Min BH, et al., Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9081-5
J:26788 Kaufman DL, et al., Characterization of the murine mu opioid receptor gene. J Biol Chem. 1995 Jun 30;270(26):15877-83
J:28030 Rossi GC, et al., Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor. FEBS Lett. 1995 Aug 7;369(2-3):192-6
J:38597 Sora I, et al., Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1544-9
J:57375 Pan YX, et al., Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. Mol Pharmacol. 1999 Aug;56(2):396-403
J:72887 Pan YX, et al., Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14084-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133191 Ikeda K, et al., The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice. J Neurosci. 2001 Feb 15;21(4):1334-9
J:145303 Charlton JJ, et al., Multiple actions of spinophilin regulate mu opioid receptor function. Neuron. 2008 Apr 24;58(2):238-47
J:177501 Liu XY, et al., Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids. Cell. 2011 Oct 14;147(2):447-58
J:180472 Rios C, et al., mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol. 2006 Jun;148(4):387-95
J:248248 Decaillot FM, et al., Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16045-50
J:273500 Rodriguez-Munoz M, et al., The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation. Cell Mol Life Sci. 2011 Sep;68(17):2933-49
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:322689 Trieu BH, et al., Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid. Science. 2022 Mar 11;375(6585):1177-1182
J:322698 Inturrisi CE, et al., Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4