Sequence Detail

ID/Version

P43028 Q70UT4 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Growth/differentiation factor 6; Short=GDF-6;AltName: Full=Bone morphogenetic protein 13; Short=BMP-13;AltName: Full=Growth/differentiation factor 16;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 454 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gdf6	growth differentiation factor 6	33	106	4	6

Sequence references in MGI

J:17582 Storm EE, et al., Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments]. Nature. 1994 Apr 14;368(6472):639-43
J:83132 Settle SH Jr, et al., Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003 Feb 1;254(1):116-30
J:101432 Mazerbourg S, et al., Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005 Sep 16;280(37):32122-32
J:193835 Asai-Coakwell M, et al., Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Hum Mol Genet. 2013 Apr 1;22(7):1432-42
J:205290 Sartori R, et al., BMP signaling controls muscle mass. Nat Genet. 2013 Nov;45(11):1309-18
J:213092 Wang SS, et al., Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. FEBS J. 2013 Jun;280(11):2644-51
J:229306 Indjeian VB, et al., Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Cell. 2016 Jan 14;164(1-2):45-56