Sequence Detail

ID/Version

P43136 Q922G8 Q61504 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 2 group F member 6;AltName: Full=COUP transcription factor 3; Short=COUP-TF3;AltName: Full=V-erbA-related protein 2; Short=EAR-2;

Provider

SWISS-PROT

Sequence

Polypeptide 390 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr2f6	nuclear receptor subfamily 2, group F, member 6	22	117	4	7

Sequence references in MGI

J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
J:19649 Jonk LJ, et al., Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors. Mech Dev. 1994 Jul;47(1):81-97
J:70599 Huggins GS, et al., Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter. J Biol Chem. 2001 Jul 27;276(30):28029-36
J:96328 Warnecke M, et al., Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes Dev. 2005 Mar 1;19(5):614-25
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139691 Hermann-Kleiter N, et al., The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity. Immunity. 2008 Aug;29(2):205-16
J:210930 Liu X, et al., Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res. 2003 May 16;92(9):1033-40
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89