Sequence Detail

ID/Version

P43404 Q80VV2 Q8CHJ3 P97455 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Tyrosine-protein kinase ZAP-70; EC=2.7.10.2;AltName: Full=70 kDa zeta-chain associated protein;AltName: Full=Syk-related tyrosine kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 618 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zap70	zeta-chain (TCR) associated protein kinase	66	100	3	36

Sequence references in MGI

J:18500 Gauen LK, et al., Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol. 1994 Jun;14(6):3729-41
J:27768 Negishi I, et al., Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature. 1995 Aug 3;376(6539):435-8
J:41170 Wiest DL, et al., A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997 Jun;6(6):663-71
J:76854 Pandey A, et al., A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem. 2002 May 24;277(21):19131-8
J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
J:82492 Tanaka Y, et al., SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity. 2003 Mar;18(3):403-14
J:88487 Kuroyama H, et al., Identification of a novel isoform of ZAP-70, truncated ZAP kinase. Biochem Biophys Res Commun. 2004 Mar 19;315(4):935-41
J:90684 Ohtsuka M, et al., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8126-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113565 Gu Y, et al., RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol. 2006 Nov;7(11):1182-1190
J:125879 Palacios EH, et al., Distinct roles for Syk and ZAP-70 during early thymocyte development. J Exp Med. 2007 Jul 9;204(7):1703-15
J:232930 Hu H, et al., Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016 Mar 7;213(3):399-414