Sequence Detail

ID/Version

P48678 P97859 Q3TTS8 Q9DC21 B3RH24 Q3UCJ8 Q91WF2 B3RH23 Q3UCU3 P11516 Q3UCA0 Q3U7I5 Q3TIH0 Q3U733 (UniProt | EBI)

Last sequence update: 2006-01-24
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Prelamin-A/C;Contains: RecName: Full=Lamin-A/C;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 665 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lmna	lamin A	71	109	3	138

Sequence references in MGI

J:3919 Nakajima N, et al., Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence. Biochim Biophys Acta. 1993 Jan 23;1171(3):311-4
J:16565 Riedel W, et al., Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence. Biochim Biophys Acta. 1989 Jun 1;1008(1):119-22
J:18494 Furukawa K, et al., Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice. Exp Cell Res. 1994 Jun;212(2):426-30
J:25971 Nakajima N, et al., Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins. FEBS Lett. 1995 May 29;365(2-3):108-14
J:58702 Sullivan T, et al., Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol. 1999 Nov 29;147(5):913-20
J:75378 De Sandre-Giovannoli A, et al., Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am J Hum Genet. 2002 Mar;70(3):726-36
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104409 Crisp M, et al., Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006 Jan 2;172(1):41-53
J:109072 Haque F, et al., SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol. 2006 May;26(10):3738-51
J:123768 Coffinier C, et al., From the Cover: HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13432-7
J:138280 Bengtsson L, et al., LUMA interacts with emerin and influences its distribution at the inner nuclear membrane. J Cell Sci. 2008 Feb 15;121(Pt 4):536-48
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:146197 Mejat A, et al., Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J Cell Biol. 2009 Jan 12;184(1):31-44
J:154595 Ostlund C, et al., Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009 Nov 15;122(Pt 22):4099-108
J:159127 Haque F, et al., Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010 Jan 29;285(5):3487-98
J:164709 Zhang YQ, et al., Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J Cell Biol. 2008 Jul 14;182(1):35-9
J:172372 Li W, et al., Decreased bone formation and osteopenia in lamin a/c-deficient mice. PLoS One. 2011;6(4):e19313
J:173222 Ahmady E, et al., Identification of a Novel Muscle A-type Lamin-interacting Protein (MLIP). J Biol Chem. 2011 Jun 3;286(22):19702-13
J:197280 Borrego-Pinto J, et al., Samp1 is a component of TAN lines and is required for nuclear movement. J Cell Sci. 2012 Mar 1;125(Pt 5):1099-105
J:198543 Cohen TV, et al., Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2alpha. Hum Mol Genet. 2013 Jul 15;22(14):2852-69
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:227485 Huang ZP, et al., Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 2;125(11):4122-34
J:244335 Liu B, et al., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun. 2013;4:1868
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:282942 Karoutas A, et al., The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nat Cell Biol. 2019 Oct;21(10):1248-1260
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302624 Tong J, et al., Lamin A/C deficiency is associated with fat infiltration of muscle and bone. Mech Ageing Dev. 2011 Nov-Dec;132(11-12):552-9
J:343395 Turgay Y, et al., The molecular architecture of lamins in somatic cells. Nature. 2017 Mar 9;543(7644):261-264