Sequence Detail

ID/Version

P49282 Q8BWV3 Q8VCU6 Q8BJL2 O54903 Q8CFA0 Q3UFV5 (UniProt | EBI)

Last sequence update: 2009-09-22
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Natural resistance-associated macrophage protein 2; Short=NRAMP 2;AltName: Full=Divalent cation transporter 1;AltName: Full=Divalent metal transporter 1; Short=DMT-1;AltName: Full=Solute carrier family 11 member 2;

Provider

SWISS-PROT

Sequence

Polypeptide 568 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	135	102	3	22

Sequence references in MGI

J:23153 Gruenheid S, et al., Identification and characterization of a second mouse Nramp gene. Genomics. 1995 Jan 20;25(2):514-25
J:42052 Fleming MD, et al., Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997 Aug;16(4):383-6
J:55729 Canonne-Hergaux F, et al., Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999 Jun 15;93(12):4406-17
J:79205 Hubert N, et al., Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12345-50
J:98088 Gunshin H, et al., Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest. 2005 May 2;115(5):1258-1266
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:115416 Canonne-Hergaux F, et al., Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001 Dec 15;98(13):3823-30
J:121724 Ludwiczek S, et al., Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med. 2007 Apr;13(4):448-54
J:142420 Foot NJ, et al., Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008 Nov 15;112(10):4268-75
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:236091 Mackenzie K, et al., Regulation of the divalent metal ion transporter via membrane budding. Cell Discov. 2016;2:16011
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89