Sequence Detail

ID/Version

P49586 Q542W4 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Choline-phosphate cytidylyltransferase A; EC=2.7.7.15 {ECO:0000269|PubMed:12842190};AltName: Full=CCT-alpha;AltName: Full=CTP:phosphocholine cytidylyltransferase A; Short=CCT A; Short=CT A;AltName: Full=Phosphorylchol

Provider

SWISS-PROT

Sequence

Polypeptide 367 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcyt1a	phosphate cytidylyltransferase 1, choline, alpha isoform	36	109	4	18

Sequence references in MGI

J:16168 Rutherford MS, et al., The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16. Genomics. 1993 Dec;18(3):698-701
J:40481 Tang W, et al., The structure of the gene for murine CTP:phosphocholine cytidylyltransferase, Ctpct. Relationship of exon structure to functional domains and identification of transcriptional start sites and potential upstream regulatory elements. J Biol Chem. 1997 May 16;272(20):13146-51
J:84309 Karim M, et al., Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta. 2003 Jul 4;1633(1):1-12
J:97657 Wang L, et al., Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a). Mol Cell Biol. 2005 Apr;25(8):3357-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:148370 Fagone P, et al., CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination. J Biol Chem. 2009 Mar 13;284(11):6847-54
J:172833 Chen BB, et al., Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. Mol Cell Biol. 2011 May;31(9):1905-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89